Dr. Stephen Freedman and his team conducted a double-blind randomized clinical trial in six pediatric hospitals in Canada. They enrolled more than 1,000 children aged six months to 18 years and found that ondansetron, a well-tolerated and safe anti-nausea drug, can prevent vomiting when given at home.  

In the study, Multidose Ondansetron after Emergency Visits in Children with Gastroenteritis published in The New England Journal of Medicine, children administered ondansetron were less likely to have moderate-to-severe symptoms after ED discharge. 

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